Diclofenac Topical vs Topicaine Comparison - Drugs.com (2025)

Prescription and OTC

Prescribed for Back Pain, Osteoarthritis, Pain, Keratosis. Diclofenac topical may also be used for purposes not listed in this medication guide.

Over-the-counter

Prescribed for Hemorrhoids, Anal Itching, Pain, Local Anesthesia, Burns - External. Topicaine may also be used for purposes not listed in this medication guide.

Related suggestions

Pain

  • Tramadol
  • Gabapentin
  • Ibuprofen
  • Acetaminophen
  • Oxycodone
  • Tylenol
More aboutDiclofenac topicalMore aboutTopicaine(lidocaine)Ratings & Reviews

Diclofenac topical has an average rating of7.0 out of 10 from a total of466 ratings on Drugs.com.63% of reviewers reported a positive effect, while 25% reported a negative effect.

Be the first to share your experience with this drug.

View all 466 reviews

Review this drug

Side Effects Experienced by UsersSide effects are reported in Drugs.com user reviews and not clinically verified.
  • Itching (3.2%)
  • Burning (3.0%)
  • Upset stomach (2.1%)
  • Allergic reaction (1.9%)
  • Rash (1.9%)
  • Nausea (1.7%)
  • Pain (1.3%)

View all Diclofenac topical side effects

View all Topicaine side effects

Drug Class
  • Topical non-steroidal anti-inflammatories
  • Topical anesthetics
Generic Availability

Lower cost generic

See Also
Herbal-Synthetic Drug Combinations in Emulgels: A Novel Approach for Enhanced Topical TherapyFormulation And Evaluation of Harbel Gel of Berberis Aristata for Anti-Psoriatic ActivityTopical Drugs Contract Manufacturing Market Report, 2033Online Topical Tretinoin Prescription | Walgreens

Lower cost generic approvedPricing and Coupons* Prices are without insurance
Quantity50 gram(s)
Strength1%
Per unit*$0.24
Cost*$12.05

View all Diclofenac topical prices

Quantity10 gram(s)
Strength5%
Per unit*$1.60
Cost*$15.98

View all Topicaine prices

Get free Discount Card

Get free Discount Card

Dosage Forms
  • Topical film, extended release
  • Topical gel
  • Topical solution
  • Topical gel
Brand NamesAspercreme Arthritis Pain Relief Gel, Diclozor, Flector Patch, Licart, Pennsaid, Profinac, Solaraze, Voltaren Arthritis Pain Gel, XrylixView moreOther lidocaine brands include: Aloe Vera Burn Relief Spray with Lidocaine, AneCream, AneCream with Tegaderm, Anestacon, Anestafoam, Apicaine-X, Aspercreme Maximum Strength Lidocaine Creme, Aspercreme Maximum Strength Lidocaine Patch, Astero, Bactine, Bruselix Cream, Bruselix Gel, CidalEaze, Derma Numb, DermacinRx Lido V Pak, DermacinRx Lidotral, DermacinRx PHN Pak, Dermaflex, Eha Lotion, Ela-Max, Ela-Max 5, Gen7T Lotion, Gen7T Patch, Glydo, LidaMantle, Lido-K, Lido-Sorb, Lidocaine Viscous, Lidocan II, Lidocan III, Lidocan IV, Lidocan Patch, Lidocan V, Lidocan VI, Lidocan VII, Lidocanna, Lidocream, Lidoderm, Lidogel, LidoLite, Lidopac, Lidopin, Lidorex, LidoRx, Lidosol, Lidotral, Lidotral 5% Gel, Lidotral Two Percent, Lidotran, Lidotrans 5 Pak, Lidovex, Lidozion, Lidozol, LMX 4, LMX 4 with Tegaderm, LMX 5, LTA II Kit, Lydexa, Medi-Quik Spray, Moxicaine, Neurozyl, RadiaGuard, RectiCare, Regenecare HA Spray, Tranzarel, Tridacaine II, Tridacaine III, Tridacaine XL, Trilocaine, Uro-Jet, Uro-Jet AC, Xylocaine Jelly, Xylocaine Topical, Zensa, Zionodil, ZTlidoView moreHalf LifeDrug half-life is the time required for plasma concentration to reduce to half its original value.

1.8 hours

N/A

CSA Schedule 1View glossary of CSA terms

N

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

C

Category CRisk cannot be ruled out

Prior To 30 Weeks Gestation

D

Category DPositive evidence of risk

Starting At 30 Weeks Gestation

See the full pregnancy warnings document.

B

Category BNo proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 128 drugs are known to interact with Diclofenac topical:

  • 9 major drug interactions (25 brand and generic names)
  • 119 moderate drug interactions (443 brand and generic names)

A total of 79 drugs are known to interact with Topicaine:

  • 2 major drug interactions (3 brand and generic names)
  • 70 moderate drug interactions (597 brand and generic names)
  • 7 minor drug interactions (20 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions
  • Asthma
  • Fluid retention
  • Renal dysfunction
  • Platelet aggregation inhibition
  • Teething pain
  • Cardiovascular dysfunction
  • Hepatic dysfunction
  • Renal dysfunction
  • Seizures
First Approval Date

October 16, 2000

N/A

WADA ClassView classifications

N/A

N/A

More Information
  • Side effects
  • Drug interactions
  • Dosage
  • Pricing and coupons
  • Pregnancy warnings
  • Breastfeeding warnings
  • Side effects
  • Drug interactions
  • Dosage
  • Pricing and coupons
  • Pregnancy warnings
  • Breastfeeding warnings
Patient Resources
  • Diclofenac topical uses
  • Advanced reading
  • Topicaine uses
  • Advanced reading
Professional Resources
  • Monograph (AHFS)
  • Prescribing information

N/A

Related Treatment Guide
  • Back Pain
  • Osteoarthritis
  • Pain
  • Keratosis
  • Hemorrhoids
  • Anal Itching
  • Pain
  • Local Anesthesia
  • Burns - External
Diclofenac Topical vs Topicaine Comparison - Drugs.com (2025)

References

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